Key result
Aortic valve basement membranes show nanoscale topography with no difference between fibrosal and ventricular surfaces.
Population
Native aortic valve endothelial basement membrane
Comparison
Quantitative characterization of topographic… vs Fibrosal versus ventricular surfaces of the cusp
Design
Preclinical
Authors
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Sub-100 nm aortic valve topography may guide scaffold design; leaves open whether replication improves tissue-engineered valve durability.
The native aortic valve basement membrane possesses sub-100 nm topographic features that can inform the design of extracellular scaffolds for tissue-engineered heart valves.
Brody et al. (2006) studied Aortic heart valve tissue engineering. Quantitative characterization of topographic features was evaluated on Topographic features of the native aortic valve endothelial basement membrane. The aortic valve basement membrane possesses a 3-D nanoscale topography of pores, fibers, and elevations in the sub-100 nm range, with no statistical difference between fibrosal and ventricular surfaces.
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