What is the clinical evidence from this study?

Study design: Observational. Population: Central arterial stiffness (n=1540). Intervention: Plasma TG-HDL-c ratio and homocysteine levels vs. Lower levels. Primary outcome: Carotid-femoral pulse wave velocity (cfPWV) (p=<0.05).

What does this research mean for the field?

Higher plasma TG-HDL-c ratio and homocysteine levels are independently associated with increased central arterial stiffness as measured by carotid-femoral pulse wave velocity. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 16, 2015Angiology

Multimarker Analysis for New Biomarkers in Relation to Central Arterial Stiffness and Hemodynamics in a Chinese Community-Dwelling Population

Q: What are the key findings of this study?

Higher plasma TG-HDL-c ratio and homocysteine levels were significantly associated with increased central arterial stiffness, indicated by higher carotid-femoral pulse wave velocity (P < 0.05).

Q: What does this research mean for the field?

Higher plasma TG-HDL-c ratio and homocysteine levels are independently associated with increased central arterial stiffness as measured by carotid-femoral pulse wave velocity. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Higher TG-HDL-c ratio and homocysteine levels linked to increased central arterial stiffness.

P<0.05
n=1,540

Why the study?

Are new biomarkers associated with central arterial stiffness and hemodynamics in a Chinese community-dwelling population?

Population

1540 Chinese community-dwelling participants, median age 62 years (range 21-96), 40.5% male.

Design

Cross-sectional

Authors

SFShihui FuThe University of Texas MD Anderson Cancer Center LLLeiming LuoHeart Failure & Transplant PYPing YePDK International

Discussion

Member takes

Implication

Hypothesis-generating for TG-HDL-c ratio and homocysteine as stiffness biomarkers; prospective validation required before clinical adoption.

Study Design

Type

Observational (n=1,540)

Structured PICO

Are new biomarkers associated with central arterial stiffness and hemodynamics in a Chinese community-dwelling population?

Population

1,540 Chinese community-dwelling adults (median age 62, 59.5% female) evaluated for associations between novel biomarkers and central arterial stiffness.

Outcome

Central arterial stiffness and hemodynamics measured by carotid-femoral pulse wave velocity (cfPWV), central pulse pressure (cPP), and central augmentation index (cAIx)surrogate

Main Result

p-value: p=<0.05

Plasma TG-HDL-c ratio and homocysteine levels are potential biomarkers for increased arterial stiffness in community-dwelling populations.

Cite This Study

Fu et al. (2015) conducted an observational in Central arterial stiffness (n=1,540). Plasma TG-HDL-c ratio and homocysteine levels vs. Lower levels was evaluated on Carotid-femoral pulse wave velocity (cfPWV) (p=<0.05). Higher plasma TG-HDL-c ratio and homocysteine levels were significantly associated with increased central arterial stiffness, indicated by higher carotid-femoral pulse wave velocity (P < 0.05).

synapsesocial.com/papers/6aa4dba76803e1e7a1f2dc89 https://doi.org/10.1177/0003319715573910

Topics

Women and heart disease

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Implication

Hypothesis-generating for TG-HDL-c ratio and homocysteine as stiffness biomarkers; prospective validation required before clinical adoption.

Multimarker Analysis for New Biomarkers in Relation to Central Arterial Stiffness and Hemodynamics in a Chinese Community-Dwelling Population

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Multimarker Analysis for New Biomarkers in Relation to Central Arterial Stiffness and Hemodynamics in a Chinese Community-Dwelling Population

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider