Multimarker Approach to Evaluate Correlates of Vascular Stiffness
Key result
A panel of 7 circulating biomarkers was significantly associated with 5 vascular stiffness measures (P<0.003 for all), with aldosterone-to-renin ratio positively associated with each measure.
Population
2000 Framingham Offspring Study participants (mean age, 61 years; 55% women)
Design
Cross-sectional
Follow-up
3 years
Authors
Discussion
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Implication
Association with vascular stiffness is hypothesis-generating; prospective studies needed before any clinical consideration.
Key Points
- This research aims to identify the biomarkers associated with vascular stiffness and their underlying biological pathways.
- Analyzed 7 biomarkers related to different biological pathways in 2000 participants, mean age 61 years.
- Measured vascular stiffness using 5 different vascular function measures after a 3-year gap.
- Utilized multivariable linear regression models to assess associations between biomarkers and vascular measures.
- The biomarker panel showed significant patterns associated with all vascular measures (P<0.003).
- The aldosterone-to-renin ratio had strong positive associations with each stiffness measure (P≤0.002).
- C-reactive protein and plasminogen activator inhibitor-1 were independently linked to specific stiffness indicators.
Study Design
Type
Cross-Sectional (n=2,000)
Structured PICO
P
Population
2000 Framingham Offspring Study participants (mean age 61 years, 55% women) evaluated for correlates of vascular stiffness.
O
Outcome
5 vascular function measures (central pulse pressure, carotid-femoral pulse-wave velocity, mean arterial pressure, forward pressure wave amplitude, and augmented pressure)surrogate
Main Result
p-value: p=<0.003
Cite This Study
Lieb et al. (2008) conducted a cross-sectional in Vascular stiffness (n=2,000). 7 circulating biomarkers was evaluated on 5 vascular function measures (central pulse pressure, carotid-femoral pulse-wave velocity, mean arterial pressure, forward pressure wave amplitude, and augmented pressure) (p=<0.003). A panel of 7 circulating biomarkers was significantly associated with 5 vascular stiffness measures (P<0.003 for all), with aldosterone-to-renin ratio positively associated with each measure.