Key result
Neurocardiogenic syncope linked to ~31% lower baroreceptor sensitivity versus controls, especially in the vasodepressive type.
Why the study?
Does baroreceptor sensitivity and forearm blood flow response during head-up tilt differ between patients with neurocardiogenic syncope and normal controls?
Population
65 subjects: 39 patients with neurocardiogenic syncope and positive tilt test, and 26 normal subjects with…
Comparison
Head-up tilt test with noninvasive assessment of… vs Normal subjects with negative tilt test.
Design
Case-control
Authors
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Hypothesis-generating in neurocardiogenic syncope; does not support baroreflex testing in practice pending prospective validation.
Case-Control (n=65)
Does baroreceptor sensitivity and forearm blood flow response during head-up tilt differ between patients with neurocardiogenic syncope and normal controls?
Absolute Event Rate: 7.2% vs 10.4%
p-value: p=0.01
Patients with neurocardiogenic syncope exhibit impaired, unstable, and disorganized baroreflexes, with impairment predominating in the vasodepressive type and instability in the cardioinhibitory type.
Flevari et al. (2002) conducted a case-control in Neurocardiogenic syncope (n=65). Neurocardiogenic syncope vs. Normal subjects with negative tilt test was evaluated on Baroreceptor sensitivity (BRS) (p=0.01). Neurocardiogenic syncope is associated with impaired baroreceptor sensitivity compared to controls (7.2 vs 10.4 ms/mmHg, P=0.01), especially in the vasodepressive type.
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