Key result
Childhood anthracycline exposure linked to reduced myocardial thickness and increased afterload.
Why the study?
Does prior anthracycline chemotherapy impair left ventricular geometry and systolic/diastolic function in children?
Population
192 children, comprising 101 children treated with anthracyclines for at least 12 months and 91 healthy…
Comparison
Prior anthracycline chemotherapy vs Healthy children (no anthracycline exposure)
Design
Cross-sectional
Follow-up
at least 12 months post-treatment
Authors
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Supports surveillance for LV geometric changes after anthracyclines in children; leaves open added value of midwall shortening.
Cross-Sectional (n=192)
Does prior anthracycline chemotherapy impair left ventricular geometry and systolic/diastolic function in children?
Late anthracycline cardiotoxicity in children is characterized by reduced myocardial thickness and increased afterload, and midwall fractional shortening does not provide additional value over endocardial shortening for identifying heart failure risk.
Iarussi et al. (2001) conducted a cross-sectional in Late cardiotoxicity (n=192). Anthracycline chemotherapy vs. Healthy children was evaluated on Left ventricular geometry and function (systolic and diastolic indices). Children treated with anthracyclines exhibited reduced myocardial thickness and increased afterload, with midwall shortening non-significantly increasing detection of depressed function from 3% to 6%.
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