Key result
Strong muscle biopsy MxA expression is linked to lower CMAS and MMT8 scores in JDM.
Why the study?
Does MxA protein expression correlate with muscle disease activity and autoantibody specificities in patients with juvenile dermatomyositis?
Population
103 patients with juvenile dermatomyositis enrolled in the Juvenile Dermatomyositis Cohort and Biomarker…
Design
Cohort
Authors
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MxA staining may support activity assessment in JDM biopsies; leaves open its utility for prognosis or MSA-guided therapy.
Cohort (n=103)
Does MxA protein expression correlate with muscle disease activity and autoantibody specificities in patients with juvenile dermatomyositis?
p-value: p=0.002
MxA protein expression on muscle biopsies correlates with clinical measures of muscular disease activity and myositis-specific autoantibody status in juvenile dermatomyositis.
Soponkanaporn et al. (2018) conducted a cohort in Juvenile dermatomyositis (n=103). MxA protein expression vs. No or weak MxA expression was evaluated on Childhood Myositis Assessment Scale (CMAS) and Manual Muscle Testing of Eight Muscles (MMT8) scores (p=0.002). Strong MxA protein expression on muscle biopsies was significantly associated with lower Childhood Myositis Assessment Scale scores (P=0.002) and Manual Muscle Testing scores (P=0.026) in JDM patients.
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