Key result
Trypanosoma evansi infection degrades murine cardiomyocytes, driving mitochondrial and myofibrillar destruction.
Population
NMRI Mus musculus (mice)
Design
Preclinical
Follow-up
From day 3 post-infection until death
Authors
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Alerts to potential cardiac complications in T. evansi infection; leaves open translation to natural hosts and clinical settings.
Experimental T. evansi infection in mice induces progressive, deleterious ultrastructural changes in cardiac myocytes and microvasculature, contributing to host death.
Tejero et al. (2018) studied Trypanosoma evansi infection (n=40). Trypanosoma evansi experimental infection vs. T. evansi-free elution buffer was evaluated on Ultrastructural changes in cardiac muscle and microvasculature assessed by transmission electron microscopy. Experimental infection with Trypanosoma evansi induced progressive, deleterious ultrastructural changes in murine cardiac myocytes and microvasculature, including mitochondrial degeneration and myofibrillar destruction.
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