Key result
Experimental Trypanosoma and Leishmania infections induce cytoarchitectural changes and necrosis in murine cardiac and systemic tissues.
Why the study?
The ultrastructural tissue alterations caused by Trypanosoma evansi, Trypanosoma cruzi, and Leishmania mexicana in mice were not fully characterized.
Experimental murine cardiac changes do not warrant clinical practice shifts; leaves open human disease relevance.
The ultrastructural study in different tissues of mice experimentally infected with isolates of Trypanosoma evansi, Trypanosoma cruzi, and Leishmania mexicana reveals changes in cardiac myocytes, skeletal muscle fibers, and hepatic, adrenal, kidney, and spleen cells. Some of these changes were cytoarchitectural and others consisted of necrosis. Alterations in the microvasculature were also found. The mononuclear cell infiltrate included neutrophils, eosinophils, and macrophages. This work shows that diverse mice tissues are important target for trypanosomatids.
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Finol et al. (2014) studied Experimental trypanosomatid infection (n=40). Trypanosomatid infection (T. cruzi, T. evansi, L. mexicana) vs. Uninfected control mice was evaluated on Ultrastructural tissue alterations. Experimental infection with Trypanosoma evansi, Trypanosoma cruzi, and Leishmania mexicana induced cytoarchitectural changes and necrosis across diverse murine tissues including cardiac, skeletal, hepatic, adrenal, kidney, and spleen cells.
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