Key result
Healthy young females exhibit lower postprandial triacylglycerol levels than males following a low-fat meal.
Why the study?
Do sex and BMI influence postprandial triacylglycerol metabolism after a low fat meal in healthy young persons?
Cross-Sectional (n=112)
No
Do sex and BMI influence postprandial triacylglycerol metabolism after a low fat meal in healthy young persons?
Absolute Event Rate: -0.52% vs -0.009%
p-value: p=<0.05
Gender and BMI significantly influence postprandial triacylglycerol metabolism in youth, with overweight young males exhibiting abnormal TG metabolism after a low-fat meal.
Sex differences in postprandial TG may exist in healthy youth; hypothesis-generating and requires prospective studies before clinical relevance.
BACKGROUND: The elevated postprandial triacylglycerol (TG) concentration is associated with elevated coronary artery disease. Oral fatty tolerant test (OFTT) is less performed in the health. This study was to evaluate the effect of sex and body mass index (BMI) on postprandial TG concentration of the low fat meal in healthy young persons. This study included 112 healthy college students (18.8+/-1.6 y). Their body height and weight were measured for body mass index (BMI). According to BMI, 27 subjects were in the under-weight subgroup, 60 in the normal weight subgroup and 25 in the over-weight subgroup. After overnight fasting low fat OFTT (27 g fat, 600 kcal) was performed and the plasma TG and glucose concentrations were measured before and at 2, 4 and 6 hour after a fat meal. The area under the curve (AUC) of TG was calculated. RESULTS: The fasting TG levels were similar and the fasting TG levels gradually increased as BMI increased in both sexes. The postprandial TG levels at 2 and 4 h decreased in female, but did not significant change in male. In female, the TG curves of 3 BMI subgroups showed saddle type, but in male the TG curve of the over-weight subgroup had a peak at 2 h, on the other hand the TG curve of under- weight subgroup had a dip at 2 h. CONCLUSIONS: Gender and BMI are important influencing factors for TG metabolism after fat meal in the youth. The young male persons with over-BMI have abnormal TG metabolism.
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Li et al. (2011) conducted a cross-sectional in Healthy (n=112). Female sex vs. Male sex was evaluated on Triacylglycerol area under the curve (TG-AUC) (p=<0.05). In healthy young adults, females had a significantly lower postprandial triacylglycerol area under the curve compared to males (-0.52 vs -0.009 h mmol/L, p<0.05) following a low-fat meal.
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