Key result
INOCA is linked to ~79% higher IL-6 levels versus healthy controls.
Why the study?
The study was conducted to investigate the relation between levels of inflammatory factors and the clinical course of ischemic heart disease with and without coronary atherosclerosis.
Population
105 patients with stable IHD and 20 healthy controls
Comparison
INOCA vs stable IHD with >50% stenosis vs healthy controls
Authors
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IL-6 elevation signals systemic inflammation in stable IHD independent of obstruction; leaves open whether IL-6 inhibition improves outcomes.
Cross-Sectional (n=125)
No
Absolute Event Rate: 4.4% vs 2.46%
p-value: p=0.027
Systemic inflammation, as measured by IL-6, is elevated in patients with stable ischemic heart disease regardless of the presence of obstructive coronary atherosclerosis.
Tseluyko et al. (2021) conducted a cross-sectional in Stable ischemic heart disease (n=125). Ischemia with non-obstructive coronary arteries (INOCA) vs. Healthy controls was evaluated on Interleukin-6 (IL-6) level (pg/ml) (p=0.027). Patients with ischemia and non-obstructive coronary arteries had significantly higher median interleukin-6 levels (4.40 pg/ml) compared to healthy controls (2.46 pg/ml).
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