Key result
Ischemic heart disease was associated with significantly elevated serum levels of IL-6, sIL-6R, and TNF-α (P<0.05) compared to healthy age-matched controls.
Why the study?
Immunological mediators play a role in the development and pathogenesis of ischemic heart disease, warranting evaluation of IL-6, TNF-alpha, and IL-6 receptor changes in these patients.
Are serum levels of IL-6, TNF-α, and sIL-6R elevated in patients with ischemic heart disease compared to healthy controls?
Population
60 IHD patients aged 40-85 years and 30 age-matched controls
Comparison
IHD patients vs age-matched controls
Design
Case-control study
Authors
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Supports a role for systemic inflammation in ischemic heart disease; leaves open whether targeting these specific cytokine pathways improves.
Case-Control (n=90)
Are serum levels of IL-6, TNF-α, and sIL-6R elevated in patients with ischemic heart disease compared to healthy controls?
p-value: p=<0.05
Increased concentrations of inflammatory markers IL-6, sIL-6R, and TNF-α are associated with ischemic heart disease, suggesting a role in coronary endothelial dysfunction.
Almadany et al. (2026) conducted a case-control in Ischemic heart disease (n=90). Ischemic heart disease vs. Healthy age-matched controls was evaluated on Serum levels of IL-6, sIL-6R, and TNF-α (p=<0.05). Ischemic heart disease was associated with significantly elevated serum levels of IL-6, sIL-6R, and TNF-α (P<0.05) compared to healthy age-matched controls.
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