March 1, 1997Coronary Artery Disease
Altered plasma levels of cytokines in patients with ischemic heart disease
Why the study?
Are plasma levels of cytokines altered in patients with ischemic heart disease compared to controls?
Population
47 individuals (31 patients with ischemic heart disease and 16 controls)
Design
Case-control
Authors
Discussion
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Member takes
Implication
These cytokine differences in IHD should not change practice; leaves open causal, biomarker, or therapeutic roles.
Structured PICO
Are plasma levels of cytokines altered in patients with ischemic heart disease compared to controls?
P
Population
47 individuals (31 patients with ischemic heart disease and 16 controls)
C
Comparator
Controls (n=16)
O
Outcome
Plasma levels of cytokines (interleukin-6, macrophage-colony-stimulating factor [MCSF], transforming growth factor-beta [TGF-beta], and seven other major cytokines)surrogate
Alterations in plasma levels of MCSF (elevated) and TGF-beta (reduced) may be involved in the pathogenesis of ischemic heart disease.
Cite This Study
Tashiro et al. (1997) studied this question.