November 1, 2001Coronary Artery Disease
Elevated interleukin-1β in pericardial fluid of patients with ischemic heart disease
Key result
Pericardial IL-1beta was significantly higher in ischemic heart disease (60 pg/ml) compared to valvular (29 pg/ml) or congenital heart disease (26 pg/ml) (P<0.05).
Why the study?
Are cytokine concentrations in pericardial fluid elevated in patients with ischemic heart disease compared to those with valvular or congenital heart disease?
Population
56 consecutive patients undergoing open heart surgery, including 27 with ischemic heart disease, 21 with…
Design
Cross-sectional
Authors
Discussion
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Implication
May signal local inflammation in IHD; leaves open diagnostic or therapeutic utility pending prospective studies.
Study Design
Type
Observational (n=56)
Structured PICO
Are cytokine concentrations in pericardial fluid elevated in patients with ischemic heart disease compared to those with valvular or congenital heart disease?
P
Population
56 consecutive patients undergoing open heart surgery, including 27 with ischemic heart disease (IHD), 21 with valvular heart disease (VHD), and 8 with congenital heart disease (CHD).
C
Comparator
Comparison among IHD, VHD, and CHD groups
O
Outcome
Concentrations of 10 major cytokines in pericardial fluidsurrogate
Main Result
Absolute Event Rate: 60% vs 29%
p-value: p=<0.05
Elevated IL-1beta concentrations in the pericardial fluid of patients with ischemic heart disease suggest a potential role in reflecting or promoting coronary atherosclerosis.
Cite This Study
Oyama et al. (2001) conducted an observational in Cardiovascular disease (n=56). Ischemic heart disease vs. Valvular or congenital heart disease was evaluated on Pericardial concentrations of IL-1beta (pg/ml) (p=<0.05). Pericardial IL-1beta was significantly higher in ischemic heart disease (60 pg/ml) compared to valvular (29 pg/ml) or congenital heart disease (26 pg/ml) (P<0.05).