Key result
Mouse brain-derived Japanese encephalitis vaccine loses strong recommendation in Japan due to acute disseminated encephalomyelitis.
Why the study?
Does the mouse brain-derived Japanese encephalitis vaccine cause acute disseminated encephalomyelitis (ADEM)?
Does the mouse brain-derived Japanese encephalitis vaccine cause acute disseminated encephalomyelitis (ADEM)?
The suspension of the mouse brain-derived JE vaccine in Japan due to ADEM concerns highlights the need for the upcoming tissue culture-derived vaccine.
May support transition to tissue culture-derived JE vaccines; leaves open ADEM causality with mouse brain-derived product.
Japanese encephalitis (JE) is a serious encephalitis caused by JE virus. Approximately 20% of JE patients die and 50% patients recover with neuro-psychiatric sequelae. In Japan, the number of JE patients was over 1000 per year in 1960s; however, the number decreased dramatically and has been less than 10 since 1990. Ministry of Health, Labour and Welfare suspended the strong recommendation for vaccination with the mouse brain-derived JE vaccine, because of cases who developed acute disseminated encephalomyelitis (ADEM) after vaccination with JE vaccine. However, it has not been fully confirmed on scientific bases that ADEM was caused by mouse brain-derived JE vaccine. Tissue culture derived-JE vaccine is under development. It is expected that this new vaccine will come to the market soon and that the recommendation of universal vaccination with JE vaccine will be implemented at the earliest occasion.
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Ichiro Kurane (2005) conducted a review in Japanese encephalitis. Mouse brain-derived inactivated Japanese encephalitis vaccine was evaluated. The Japanese Ministry of Health, Labour and Welfare suspended the strong recommendation for the mouse brain-derived Japanese encephalitis vaccine due to cases of acute disseminated encephalomyelitis.
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