Key result
Childhood-onset Japanese encephalitis incidence rises ~291% from 1995-2004 to 2005-2015.
Why the study?
What is the incidence and clinical profile of childhood-onset Japanese Encephalitis in Japan following the 2005 retraction of active vaccine recommendation?
Population
109 patients registered to the national surveillance with Japanese Encephalitis in Japan from 1995 to 2015…
Design
Cohort
Authors
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Increased childhood JE incidence after 2005 vaccine retraction; was associated with high sequelae rates and leaves open vaccination policy effects.
Observational (n=109)
Yes
What is the incidence and clinical profile of childhood-onset Japanese Encephalitis in Japan following the 2005 retraction of active vaccine recommendation?
Absolute Event Rate: 0.0043% vs 0.0011%
p-value: p=0.04
The incidence of childhood-onset Japanese encephalitis in Japan increased after the retraction of active vaccine recommendation in 2005, highlighting the importance of vaccination in endemic areas.
Nanishi et al. (2018) conducted an observational in Japanese encephalitis (n=109). Retraction of active recommendation of JE vaccine (2005-2015) vs. Active recommendation period (1995-2004) was evaluated on Annual incidence rate of childhood-onset JE per 100,000 (p=0.04). The annual incidence rate of childhood-onset Japanese encephalitis increased from 1.1 × 10-3 per 100,000 during 1995-2004 to 4.3 × 10-3 per 100,000 during 2005-2015 (P=0.04).
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