Histologic Hydrogen-Ion Studies of the Kidney

Studies of nephritis and renal function have included much work on the blood and urine, especially that done in connection with hydrogen-ion concentrations. They have included little work on the secreting cells, however. The present studies were undertaken in an attempt to determine what parts of the uriniferous tubules are responsible for an acid or alkaline reaction of the urine. It was felt that the localization of such determining function would yield data of value concerning the normal and pathologic physiology of the kidney. The hydrogen-ion concentrations in the secreting cells and in the urine were determined simultaneously under varying conditions. The following phases of the problem have been considered: 1. Where is the reaction of the urine determined? 2. How is it determined? 3. What effect has altering the reaction of the urine on the normal findings? 4. What effect has nephritis on the normal findings? 4. What effect