Key result
Impermeable stent grafts oversized by ~15% optimally reduce AAA wall pressure in an experimental model.
Why the study?
Does the insertion of a stent graft reduce wall pressure in an experimental AAA model?
Does the insertion of a stent graft reduce wall pressure in an experimental AAA model?
In an experimental AAA model, impermeable stent grafts sized 10-15% larger than the artery provided optimal reduction in aneurysm wall pressure.
Stent graft effects on AAA wall pressure in rubber models should not alter practice; leaves open optimal diameter and permeability for clinical use.
The purpose of this study was to investigate the influence of stent grafts on the wall pressure of aneurysms and find out what kind of stent graft is suitable for curing aneurysm. A set of experiment apparatus that simulated the human heart and artery was set up, including an elastic abdominal aortic aneurysm (AAA) model which was made of rubber. The influence of healing induced by stent grafts with different diameters and either permeable or impermeable on the AAA were investigated by comparing experiments using the AAA model with clinical stent grafts in a pulsatile flow system that simulated human blood circulation. The experiment results show that the pressure on the AAA wall reduced after the insertion of a stent graft. The permeable stent graft is not propitious to the pressure reduction. Furthermore, the reduction of pressure is related to stent graft diameter, that is, stent grafts whose diameter is 10–15% larger than the arterial diameter leads to the optimal reduction of the wall pressure. The results are unprecedented and expected to have significant clinical applications.
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Chen et al. (2013) studied Abdominal aortic aneurysm (AAA). Stent graft insertion vs. No stent graft / different stent graft types was evaluated on Wall pressure of aneurysm. Insertion of a stent graft reduced AAA wall pressure in an experimental model, with optimal reduction achieved using impermeable stent grafts 10-15% larger than the arterial diameter.
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