Key result
Oxprenolol achieves target DBP in ~46% fewer patients than propranolol when added to hydrochlorothiazide.
Why the study?
Does oxprenolol compared to propranolol improve blood pressure reduction in patients with mild to moderate hypertension not responding to hydrochlorothiazide alone?
RCT (n=260)
Double-blind
Randomized
Yes
Does oxprenolol compared to propranolol improve blood pressure reduction in patients with mild to moderate hypertension not responding to hydrochlorothiazide alone?
Absolute Event Rate: 27% vs 50%
p-value: p=<0.001
Propranolol is more effective than oxprenolol in reducing diastolic blood pressure when added to hydrochlorothiazide in patients with mild to moderate hypertension, though it is associated with a higher rate of impotence.
Propranolol should be preferred over oxprenolol as add-on to hydrochlorothiazide; confirms superior BP control in this RCT.
Oxprenolol (O) or propranolol (P) was randomly added double-blind to the regimen of 260 patients with mild and moderate hypertension who had not responded to hydrochlorothiazide (H) alone. Both beta-adrenergic blocking agents were titrated over a range of 120 to 360 mg per day while H was continued. After 6 months of treatment, reduction of diastolic blood pressure (DBP) to below 90 mm Hg and at least 5 mm Hg less than the initial DBP was achieved in 50% of patients receiving P+H and 27% of patients taking O+H (p less than 0.001). P+H lowered BP an additional 10.5/9.8 mm Hg compared with 6.8/7.0 mm Hg for O+H (p less than 0.02). Reduction in heart rate was less after O+H (average, 8.4/min) than after P+H (average, 12.3/min, p less than 0.01). The number of dropouts, morbid events, and reported side effects between the two regimens was not significantly different except that more patients complained of impotence with P+H than with O+H (p less than 0.05).
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A 1981 study conducted an RCT in Mild and moderate hypertension (n=260). Oxprenolol vs. Propranolol was evaluated on Reduction of diastolic blood pressure (DBP) to below 90 mm Hg and at least 5 mm Hg less than the initial DBP (p=<0.001). Oxprenolol was less effective than propranolol at reducing diastolic blood pressure to target levels (27% vs 50%; p<0.001) when added to hydrochlorothiazide for 6 months.
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