Key result
Exogenous NO nearly abolishes BDNF release from single-pulse stimulated rat neurons via cGMP-independent mechanisms.
Population
Cultured nodose ganglion (NG) neurons from newborn rats
Comparison
Exogenous nitric oxide, L-NAME… vs Control conditions without exogenous NO or…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether pattern-dependent BDNF regulation by nitric oxide modulates baroreflex function in vivo.
Nitric oxide regulates BDNF release from nodose ganglion neurons in a pattern-dependent and cGMP-independent manner, identifying a novel mechanism of homeostatic regulation at baroafferent synapses.
Hsieh et al. (2009) studied this question. Exogenous nitric oxide and L-NAME was evaluated on BDNF release from newborn rat nodose ganglion neurons. Exogenous nitric oxide nearly abolishes BDNF release from newborn rat nodose ganglion neurons stimulated with single pulses at 6 Hz, but not 2-pulse bursts, via a cGMP-independent mechanism.
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