Key result
Higher AHI predicts ~26% greater odds of coronary microcirculatory dysfunction in stable angina.
Why the study?
To investigate the effect and possible mechanism of obstructive sleep apnea hypopnea syndrome on coronary microcirculation in stable angina pectoris patients with a single borderline lesion.
Does the Apnea Hypopnea Index predict coronary microcirculatory dysfunction in stable angina pectoris patients with a single borderline lesion?
Observational
Does the Apnea Hypopnea Index predict coronary microcirculatory dysfunction in stable angina pectoris patients with a single borderline lesion?
Odds Ratio: 1.26 (95% CI 1.083–1.467)
p-value: p=<0.01
An Apnea Hypopnea Index >13.7 is a strong independent predictor of coronary microcirculatory dysfunction in patients with stable angina and a single borderline coronary lesion.
AHI may aid risk stratification in borderline lesions; leaves open causal links and therapeutic impact.
BACKGROUND: To investigate the effect and possible mechanism of obstructive sleep apnea hypopnea syndrome on coronary microcirculation in stable angina pectoris (SAP) patients with a single borderline lesion. METHODS: ), night average heart rate, endothelin-1 (ET-1), nitric oxide (NO) and high-sensitivity C-reactive protein in serum between the two groups. Furthermore, risk factors affecting coronary microcirculation were analyzed. RESULTS: = 0.659, 0.691, respectively). Logistic regression analysis showed that AHI was an independent predictor of coronary microcirculatory dysfunction (odds ratio = 1.260, 95% confidence interval 1.083~1.467, p < 0.01). Receiver operating characteristic (ROC) curve analysis indicated an AHI cut-off value of 13.7 times/h to predict microcirculatory dysfunction (sensitivity 0.942, specificity 0.880). CONCLUSIONS: In SAP patients with a single critical lesion, AHI was associated with coronary microcirculatory dysfunction.
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Wang et al. (2020) conducted an observational in Stable angina pectoris with a single borderline lesion. Apnea Hypopnea Index (AHI) was evaluated on Coronary microcirculatory dysfunction (OR 1.260, 95% CI 1.083-1.467, p=<0.01). Apnea Hypopnea Index was an independent predictor of coronary microcirculatory dysfunction in stable angina pectoris patients with a single borderline lesion (OR 1.260; 95% CI 1.083-1.467; p<0.01).
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