Key result
Obesity and the MnSOD V allele are linked to higher oxidative and inflammatory biomarkers.
Why the study?
Does the interaction between Ala16Val MnSOD polymorphism and obesity affect lipid, inflammatory, and oxidative blood biomarkers in adult subjects?
Cross-Sectional (n=161)
No
Does the interaction between Ala16Val MnSOD polymorphism and obesity affect lipid, inflammatory, and oxidative blood biomarkers in adult subjects?
p-value: p=0.006
The interaction between the Ala16Val MnSOD polymorphism and obesity status significantly influences lipid, oxidative, and inflammatory biomarkers, potentially modulating the risk of atherosclerosis and cardiovascular disease.
May suggest MnSOD-obesity interaction elevates biomarker risk; leaves open causal links to events or practice change.
Previous investigations suggest association between obesity and Ala16Val MnSOD gene polymorphism.The V allele produces enzyme which not catalyze the superoxide anion efficiently as occurs with A allele.As obesity is related to development of other metabolic disorders we performed a study that analyzed the effect of interaction between Ala16Val MnSOD polymorphism and obesity on lipid, oxidative and inflammatory biomarkers of adult subjects.The study enrolled 161 volunteers as categorized in six groups with different genotypes: Obeses with different genotypes (AAO, VVO and AVO) and nonobese (AANO, VVNO and AVNO).In general the group AANO presented lower values whereas VVO presented higher values of biomarkers analyzed.These results suggest that oxidative metabolism influenced by genetic status could to minimize or maximize the obesity effects on lipid, oxidative and inflammatory biomarkers that are also implicated in the genesis of important dysfunctions and diseases as atherosclerosis, diabetes 2 and cardiovascular morbidities.
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Mânica-Cattani et al. (2012) conducted a cross-sectional in Obesity (n=161). Ala16Val MnSOD polymorphism (V allele) and obesity vs. Non-obese subjects with AA genotype was evaluated on Proportion of subjects with higher OxLDL (>0.5 mg/L) (p=0.006). The interaction between obesity and the Ala16Val MnSOD V allele was associated with significantly higher levels of lipid, inflammatory, and oxidative biomarkers, such as OxLDL and hs-CRP, compared to non-obese AA carriers.
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