Key result
Higher miR-206 linked to ~95% lower risk of cerebral ischemic events in asymptomatic carotid stenosis.
Why the study?
To investigate the serum expression level of miR-206 in patients with asymptomatic carotid artery stenosis and evaluate its diagnostic and prognostic value.
Does serum miR-206 level have diagnostic and prognostic value for asymptomatic carotid artery stenosis and subsequent cerebrovascular ischemic events?
Case-Control (n=206)
No
Does serum miR-206 level have diagnostic and prognostic value for asymptomatic carotid artery stenosis and subsequent cerebrovascular ischemic events?
Hazard Ratio: 0.046 (95% CI 0.005–0.431)
p-value: p=0.007
Serum miR-206 serves as a highly accurate diagnostic biomarker for asymptomatic carotid artery stenosis and independently predicts the 5-year risk of cerebrovascular ischemic events.
May aid risk stratification in asymptomatic carotid stenosis; hypothesis-generating and requires prospective validation before clinical use.
Introduction: To investigate the expression level of miR-206 in serum of patients with asymptomatic carotid artery stenosis (CAS) and estimate the value of miR-206 in the diagnosis and prognosis of asymptomatic CAS. Methods: A total of 206 individuals enrolled in this study, including 105 CAS patients and 101 controls. RT-qPCR technology was applied to measure the relative level of miR-206, and Pearson’s correlation coefficient was performed to analyze the relationship between carotid artery stenosis degree and miR-206 level. An ROC curve was drawn to assess the diagnostic value of miR-206 in asymptomatic CAS. The 5-year prognosis of asymptomatic CAS patients was tested using multivariate Cox regression analysis and Kaplan-Meier survival curve. Results: MiR-206 expression was reduced in asymptomatic CAS patients. The AUC of the ROC curve of miR-206 was 0.939, with a sensitivity of 86.70% and a specificity of 86.14%. The amount of CAS gradually increased with the decrease of miR-206 level. Seven-teen patients in the low miR-206 expression group developed CIEs, and 3 patients in the high miR-206 expression group developed CIEs during the 5-year follow-up. miR-206 and the amount of CAS were independent factors for the occurrence of CIEs within 5 years in asymptomatic CAS patients. Conclusion: Serum miR-206 has high diagnostic accuracy for asymptomatic CAS and has predictive value for the incidence of CIEs in patients within 5 years.
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Li et al. (2022) conducted a case-control in Asymptomatic Carotid Artery Stenosis (n=206). Serum miR-206 vs. High vs low expression was evaluated on Cerebral ischemic events (CIEs) within 5 years (HR 0.046, 95% CI 0.005-0.431, p=0.007). Serum miR-206 levels were independently associated with the risk of cerebral ischemic events over 5 years in patients with asymptomatic carotid artery stenosis (HR 0.046).
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