What is the clinical evidence from this study?

Study design: Cohort. Population: Aortic stiffness (n=1121). Intervention: Alcohol consumption vs. Non-drinkers. Primary outcome: Development of aortic stiffness (aortic PWV of 8.0 m/sec or more) (RR 2.09, 95% CI 1.35-3.26, p=<0.001).

What does this research mean for the field?

Alcohol consumption is dose-dependently associated with an increased risk of developing aortic stiffness in middle-aged men, with consumption of 69.0 or more g/day more than doubling the risk compared to non-drinkers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2001Industrial HealthOpen Access

Association of Alcohol Consumption with Increase in Aortic Stiffness. A 9-Year Longitudinal Study in Middle-Aged Japanese Men.

Q: What are the key findings of this study?

Alcohol consumption of 69.0 or more g/day of ethanol significantly increased the risk of developing aortic stiffness compared to non-drinkers (RR 2.09) in middle-aged Japanese men.

Q: What does this research mean for the field?

Alcohol consumption is dose-dependently associated with an increased risk of developing aortic stiffness in middle-aged men, with consumption of 69.0 or more g/day more than doubling the risk compared to non-drinkers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Alcohol intake ≥69 g/day linked to ~109% greater risk of aortic stiffness versus non-drinkers.

RR 2.09
95% CI 1.35-3.26
P<0.001
n=1,121

Why the study?

Does alcohol consumption increase the risk of developing aortic stiffness in middle-aged men?

Population

1,121 Japanese male office workers aged 35 to 59 years, free of aortic stiffness and without definite…

Comparison

Alcohol consumption, categorized by daily… vs Non-drinkers.

Design

Cohort

Follow-up

9 years (8,872 person-years)

Authors

NNNoriyuki NakanishiTokyo University of Social Welfare HKHaruhito KawashimoTaawon KNKoji NakamuraAstellas Pharma (Japan)

Discussion

Member takes

Implication

Heavy drinking may increase aortic stiffness risk; extends observational data but leaves open causality pending randomized trials.

Study Design

Type

Cohort (n=1,121)

Multicenter

Structured PICO

Does alcohol consumption increase the risk of developing aortic stiffness in middle-aged men?

Population

1,121 middle-aged Japanese male office workers free of aortic stiffness, hypertension, hypercholesterolemia, and diabetes, followed for 9 years.

Exposure

Alcohol consumption, categorized by daily ethanol intake: 0.1-22.9 g/day, 23.0-45.9 g/day, 46.0-68.9 g/day, and ≥69.0 g/day.

Comparator

Non-drinkers.

Outcome

Development of aortic stiffness (defined as an aortic pulse wave velocity of 8.0 m/sec or more) over 9 years of follow-up.surrogate

Main Result

Relative Risk: 2.09 (95% CI 1.35–3.26)

Absolute Event Rate: 39.5% vs 30.4%

p-value: p=<0.001

Higher alcohol consumption is dose-dependently associated with an increased risk of developing aortic stiffness in middle-aged men.

Limitations

Drinkers had higher levels of blood pressure and smoked more cigarettes daily, which might explain their higher risk.
Aortic PWV is an indirect marker of aortic stiffness and is affected by various hemodynamic factors such as blood pressure.
Drinkers had higher levels of blood pressure and smoked more cigarettes daily than non-drinkers, which may confound results despite adjustment.
Aortic pulse wave velocity is an indirect marker of aortic stiffness and is affected by various hemodynamic factors such as blood pressure.

Cite This Study

Nakanishi et al. (2001) conducted a cohort in Aortic stiffness (n=1,121). Alcohol consumption vs. Non-drinkers was evaluated on Development of aortic stiffness (aortic PWV of 8.0 m/sec or more) (RR 2.09, 95% CI 1.35-3.26, p=<0.001). Alcohol consumption of 69.0 or more g/day of ethanol significantly increased the risk of developing aortic stiffness compared to non-drinkers (RR 2.09) in middle-aged Japanese men.

synapsesocial.com/papers/6aa50119c8e0620ff0f2d011 https://doi.org/10.2486/indhealth.39.24

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Association of Alcohol Consumption with Increase in Aortic Stiffness. A 9-Year Longitudinal Study in Middle-Aged Japanese Men.

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Association of Alcohol Consumption with Increase in Aortic Stiffness. A 9-Year Longitudinal Study in Middle-Aged Japanese Men.

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider