Key result
Alcohol consumption was dose-dependently associated with an increased risk of developing aortic pulse wave velocity ≥8.0 m/sec, reaching an RR of 1.81 (95% CI 1.23-2.66) for ≥69.0 g/day of ethanol.
Why the study?
Does alcohol consumption increase the risk of developing increased aortic pulse wave velocity in middle-aged Japanese men?
Population
1,358 Japanese men aged 35 to 59 years with a baseline aortic pulse wave velocity less than 8.0 m/sec and…
Comparison
Alcohol consumption vs Nondrinkers
Design
Cohort
Follow-up
9 years (10,598 person-years)
Authors
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May support moderating alcohol to mitigate arterial stiffness risk; leaves open causality pending randomized confirmation.
Cohort (n=1,358)
Does alcohol consumption increase the risk of developing increased aortic pulse wave velocity in middle-aged Japanese men?
Relative Risk: 1.81 (95% CI 1.23–2.66)
p-value: p=<0.001
Higher alcohol consumption is significantly associated with an increased risk of developing elevated aortic pulse wave velocity, a marker of arterial stiffness, in middle-aged Japanese men.
Nakanishi et al. (2001) conducted a cohort in Increased aortic pulse wave velocity (n=1,358). Alcohol consumption vs. Nondrinkers was evaluated on Development of increased aortic PWV of 8.0 m/sec or more (RR 1.81, 95% CI 1.23-2.66, p=<0.001). Alcohol consumption was dose-dependently associated with an increased risk of developing aortic pulse wave velocity ≥8.0 m/sec, reaching an RR of 1.81 (95% CI 1.23-2.66) for ≥69.0 g/day of ethanol.
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