What is the clinical evidence from this study?

Study design: Cohort. Population: Coronary artery bypass grafting (CABG) (n=4381). Intervention: Preoperative beta-blocker therapy vs. No preoperative beta-blocker therapy. Primary outcome: Post-operative stroke (adjusted OR 0.59, p=0.011).

What does this research mean for the field?

Preoperative beta-blocker therapy significantly reduces postoperative stroke but increases atrial arrhythmia in patients undergoing on-pump coronary artery bypass graft surgery. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2003Interactive Cardiovascular and Thoracic SurgeryOpen Access

Preoperative β-blocker therapy in coronary artery bypass surgery: a propensity score analysis of outcomes

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Key result

Preoperative beta-blockers are linked to ~41% fewer strokes but more atrial arrhythmias after on-pump CABG.

adjusted OR 0.59
P=0.011
n=4,381

Why the study?

Does preoperative beta-blocker therapy reduce adverse in-hospital outcomes in patients undergoing on-pump CABG?

Population

4,381 consecutive patients undergoing coronary artery bypass grafting on cardiopulmonary bypass between…

Comparison

Preoperative beta-blocker therapy (n=2,836) vs No preoperative beta-blocker therapy (n=1,545)

Design

Cohort

Follow-up

in-hospital

Authors

ASAnand SrinivasanAll India Institute of Medical Sciences Bhubaneswar

Discussion

Member takes

Implication

Warrants caution before adopting preoperative beta-blockers in on-pump CABG due to arrhythmia risk; leaves open net benefit in randomized trials.

Study Design

Type

Cohort (n=4,381)

Structured PICO

Does preoperative beta-blocker therapy reduce adverse in-hospital outcomes in patients undergoing on-pump CABG?

Population

4,381 consecutive patients undergoing on-pump coronary artery bypass grafting.

Exposure

Preoperative beta-blocker therapy (n=2,836)

Comparator

No preoperative beta-blocker therapy (n=1,545)

Outcome

In-hospital outcomes including post-operative stroke, atrial arrhythmia, operative mortality, and other morbidityhard clinical

Main Result

Odds Ratio: 0.59

p-value: p=0.011

Preoperative beta-blocker therapy in patients undergoing on-pump CABG is associated with a reduced risk of post-operative stroke but an increased risk of atrial arrhythmia.

Cite This Study

Anand Srinivasan (2003) conducted a cohort in Coronary artery bypass grafting (CABG) (n=4,381). Preoperative beta-blocker therapy vs. No preoperative beta-blocker therapy was evaluated on Post-operative stroke (adjusted OR 0.59, p=0.011). Preoperative beta-blocker therapy in patients undergoing on-pump CABG was associated with a reduction in post-operative stroke (adjusted OR 0.59, p=0.011) and an increase in atrial arrhythmia.

synapsesocial.com/papers/6aa501e33a03b8d03ddc3ed6 https://doi.org/10.1016/s1569-9293(03)00132-4

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December 1, 2003Interactive Cardiovascular and Thoracic SurgeryOpen Access

Preoperative β-blocker therapy in coronary artery bypass surgery: a propensity score analysis of outcomes

View Full Paper

Ask AI

Bookmark

Key result

Preoperative beta-blockers are linked to ~41% fewer strokes but more atrial arrhythmias after on-pump CABG.

adjusted OR 0.59
P=0.011
n=4,381

Why the study?

Does preoperative beta-blocker therapy reduce adverse in-hospital outcomes in patients undergoing on-pump CABG?

Population

4,381 consecutive patients undergoing coronary artery bypass grafting on cardiopulmonary bypass between…

Comparison

Preoperative beta-blocker therapy (n=2,836) vs No preoperative beta-blocker therapy (n=1,545)

Design

Cohort

Follow-up

in-hospital

Authors

ASAnand SrinivasanAll India Institute of Medical Sciences Bhubaneswar

Discussion

Member takes

Implication

Warrants caution before adopting preoperative beta-blockers in on-pump CABG due to arrhythmia risk; leaves open net benefit in randomized trials.

Study Design

Type

Cohort (n=4,381)

Structured PICO

Does preoperative beta-blocker therapy reduce adverse in-hospital outcomes in patients undergoing on-pump CABG?

Population

4,381 consecutive patients undergoing on-pump coronary artery bypass grafting.

Exposure

Preoperative beta-blocker therapy (n=2,836)

Comparator

No preoperative beta-blocker therapy (n=1,545)

Outcome

In-hospital outcomes including post-operative stroke, atrial arrhythmia, operative mortality, and other morbidityhard clinical

Main Result

Odds Ratio: 0.59

p-value: p=0.011

Preoperative beta-blocker therapy in patients undergoing on-pump CABG is associated with a reduced risk of post-operative stroke but an increased risk of atrial arrhythmia.

Cite This Study

synapsesocial.com/papers/6aa501e33a03b8d03ddc3ed6 https://doi.org/10.1016/s1569-9293(03)00132-4

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