What does this research mean for the field?

Neither antipsychotic nor antidepressant drug use is associated with an overall increased risk of venous thromboembolism in adults aged 65 years and older, although butyrophenone use is associated with a modest increased risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2002Thrombosis and Haemostasis

Antipsychotic and Antidepressant Drug Use in the Elderly and the Risk of Venous Thromboembolism

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Venous thromboembolism (n=131196). Intervention: Antipsychotic or antidepressant drugs vs. Thyroid replacement hormones. Primary outcome: Deep vein thrombosis (HR 1.13, 95% CI 0.96-1.32).

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Key result

Antipsychotics and antidepressants show no increased DVT risk compared to thyroid hormones.

HR 1.13
95% CI 0.96-1.32
n=131,196

Why the study?

Does antipsychotic or antidepressant drug use increase the risk of venous thromboembolism in adults aged 65 years and older?

Population

131,196 adults aged 65 years and older without antecedent history of cardiovascular disease, venous…

Comparison

Antipsychotic drugs or antidepressant drugs vs Thyroid replacement hormones (n=33,033)

Design

Cohort

Follow-up

9 years

Authors

MMMuhammad MamdaniVascular Medicine EYErik YeoVascular Medicine JRJoel G. RaySt. Michael's Hospital

Discussion

Member takes

Implication

No increased DVT risk seen with antipsychotics or antidepressants in older adults; leaves open butyrophenone effects and requires prospective confirmation.

Study Design

Type

Cohort (n=131,196)

Structured PICO

Does antipsychotic or antidepressant drug use increase the risk of venous thromboembolism in adults aged 65 years and older?

Population

131,196 adults aged ≥65 years prescribed antipsychotics, antidepressants, or thyroid hormones, free of prior cardiovascular disease, VTE, or cancer, followed over 9 years.

Exposure

Antipsychotic drugs (n=22,514) or antidepressant drugs (n=75,649)

Comparator

Thyroid replacement hormones (n=33,033)

Outcome

Diagnosis of deep vein thrombosis or pulmonary embolismhard clinical

Main Result

Hazard Ratio: 1.13 (95% CI 0.96–1.32)

In older adults, the use of antipsychotic or antidepressant drugs is generally not associated with an increased risk of venous thromboembolism, with the possible exception of butyrophenones.

Cite This Study

Mamdani et al. (2002) conducted a cohort in Venous thromboembolism (n=131,196). Antipsychotic or antidepressant drugs vs. Thyroid replacement hormones was evaluated on Deep vein thrombosis (HR 1.13, 95% CI 0.96-1.32). Neither antipsychotic (HR 1.13; 95% CI 0.96-1.32) nor antidepressant (HR 1.02; 95% CI 0.91-1.14) drug use was associated with an increased risk of deep vein thrombosis compared to thyroid hormones.

synapsesocial.com/papers/6aa50c693a03b8d03ddc3f6b https://doi.org/10.1055/s-0037-1613188

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January 1, 2002Thrombosis and Haemostasis

Antipsychotic and Antidepressant Drug Use in the Elderly and the Risk of Venous Thromboembolism

View Full Paper

Ask AI

Bookmark

Key result

Antipsychotics and antidepressants show no increased DVT risk compared to thyroid hormones.

HR 1.13
95% CI 0.96-1.32
n=131,196

Why the study?

Does antipsychotic or antidepressant drug use increase the risk of venous thromboembolism in adults aged 65 years and older?

Population

131,196 adults aged 65 years and older without antecedent history of cardiovascular disease, venous…

Comparison

Antipsychotic drugs or antidepressant drugs vs Thyroid replacement hormones (n=33,033)

Design

Cohort

Follow-up

9 years

Authors

MMMuhammad MamdaniVascular Medicine EYErik YeoVascular Medicine JRJoel G. RaySt. Michael's Hospital

Discussion

Member takes

Implication

No increased DVT risk seen with antipsychotics or antidepressants in older adults; leaves open butyrophenone effects and requires prospective confirmation.

Study Design

Type

Cohort (n=131,196)

Structured PICO

Does antipsychotic or antidepressant drug use increase the risk of venous thromboembolism in adults aged 65 years and older?

Population

131,196 adults aged ≥65 years prescribed antipsychotics, antidepressants, or thyroid hormones, free of prior cardiovascular disease, VTE, or cancer, followed over 9 years.

Exposure

Antipsychotic drugs (n=22,514) or antidepressant drugs (n=75,649)

Comparator

Thyroid replacement hormones (n=33,033)

Outcome

Diagnosis of deep vein thrombosis or pulmonary embolismhard clinical

Main Result

Hazard Ratio: 1.13 (95% CI 0.96–1.32)

In older adults, the use of antipsychotic or antidepressant drugs is generally not associated with an increased risk of venous thromboembolism, with the possible exception of butyrophenones.

Cite This Study

synapsesocial.com/papers/6aa50c693a03b8d03ddc3f6b https://doi.org/10.1055/s-0037-1613188

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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