Key result
Childhood HIV infection linked to ~38% lower poliovirus seroconversion after OPV.
Why the study?
Does HIV infection reduce the serologic response to oral polio vaccine in children?
Population
95 Zimbabwean children 2 months to 2 years of age, born to HIV-infected mothers
Comparison
Oral polio vaccine according to the national… vs HIV-uninfected children
Design
Cross-sectional
Authors
Loading...
HIV-associated lower OPV seroconversion may complicate eradication; leaves open whether modified regimens improve protection in infected children.
Cross-Sectional (n=95)
Does HIV infection reduce the serologic response to oral polio vaccine in children?
Absolute Event Rate: 60% vs 96%
p-value: p=0.001
Pediatric HIV infection is associated with a significantly poorer serologic response to the oral polio vaccine, highlighting a potential challenge for global polio eradication.
Gnanashanmugam et al. (2011) conducted a cross-sectional in HIV infection (n=95). HIV infection vs. HIV-uninfected children was evaluated on Seroconversion to poliovirus serotype 1 after ≥3 OPV doses (p=0.001). HIV infection in children was associated with significantly lower rates of seroconversion to poliovirus serotypes 1, 2, and 3 (60%, 67%, and 47% vs. 96%, 100%, and 82%) after ≥3 OPV doses.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: