Key result
Long-term PM2.5 exposure linked to a ~1% annual increase in baPWV per 10 μg/m3.
Why the study?
Prior studies investigating the association of PM2.5 exposure with arterial stiffness reported inconsistent conclusions, and limited evidence exists regarding PM2.5 exposure and the arterial stiffness index.
Does long-term exposure to PM2.5 increase the progression of arterial stiffness in a cohort population?
Cohort (n=3,951)
Does long-term exposure to PM2.5 increase the progression of arterial stiffness in a cohort population?
Mean Difference: 1.04 (95% CI 0.72–1.37)
p-value: p=<0.001
Long-term exposure to PM2.5 is associated with the progression of arterial stiffness, suggesting that improving air quality may help prevent vascular aging.
PM2.5 exposure may accelerate vascular aging; extends observational data but leaves open causality and preventive trials.
Background Prior studies have investigated the association of PM2.5 exposure with arterial stiffness measured by ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV), of which conclusions are inconsistent. Moreover, limited evidence is available on the contributory role of PM2.5 exposure on the arterial stiffness index. Methods We used the population data from the Beijing Health Management Cohort and conducted a longitudinal analysis. The annual average concentration of PM2.5 for 35 air pollutant monitoring sites in Beijing from 2014 to 2018 was used to estimate individual exposure by different interpolation methods. Multivariate logistic regression and linear regression were conducted to assess the association of annual average PM2.5 concentration with the incidence of higher baPWV, the progression of ABI, and baPWV, respectively. Results The association between PM2.5 exposure and incidence of higher baPWV was not significant (OR = 1.11, 95% CI: 0.82–1.50, P = 0.497). There was − 0.16% (95% CI: − 0.43-0.11%) decrease in ABI annually and 1.04% (95% CI: 0.72–1.37%) increase in baPWV annually with each increment of 10 μg/m3 average PM2.5 concentration. Conclusions Long-term exposure to PM2.5 was associated with the progression of arterial stiffness in Beijing. This study suggests that improvement of air quality may help to prevent arterial stiffness.
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Sun et al. (2021) conducted a cohort in Arterial stiffness (n=3,951). Fine particulate matter (PM2.5) exposure vs. Lower PM2.5 exposure was evaluated on Relative annual change of brachial-ankle pulse wave velocity (baPWV) per 10 μg/m3 increment in average PM2.5 concentration (MD 1.04%, 95% CI 0.72-1.37, p=<0.001). Long-term exposure to PM2.5 was associated with a 1.04% annual increase in brachial-ankle pulse wave velocity per 10 μg/m3 increment, indicating progression of arterial stiffness.
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