Key result
Bedtime administration of antihypertensive drugs lacks a valid evidence base due to obvious design deficiencies in the MAPEC and HYGIA chronotherapy studies.
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Design
Editorial
This commentary highlights methodological flaws in the MAPEC and HYGIA trials, challenging their conclusion that antihypertensives should be dosed at bedtime.
The recently published chronotherapeutic Spanish papers MAPEC and HYGIA proposing that antihypertensive drug treatment should be given at bedtime suffers from obvious deficiencies in study design and are not a valid basis for drug treatment of hypertension.
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Lemmer et al. (2020) studied this question. Bedtime administration of antihypertensive drugs lacks a valid evidence base due to obvious design deficiencies in the MAPEC and HYGIA chronotherapy studies.
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