Key result
Acute plasma free fatty acid elevation increases TRL apoC-III production by ~90%.
Why the study?
Does acute elevation of plasma free fatty acids via Intralipid/heparin stimulate TRL apoC-III production in healthy men?
Population
12 healthy men in the fed state
Comparison
Intralipid/heparin infusion to raise plasma free… vs Glycerol infusion and saline
Design
Other
Authors
Loading...
May link acute FFA elevation to hypertriglyceridemia via apoC-III in insulin resistance; hypothesis-generating for mechanistic validation in metabolic disease.
Does acute elevation of plasma free fatty acids via Intralipid/heparin stimulate TRL apoC-III production in healthy men?
Acute elevation of plasma free fatty acids stimulates TRL apoC-III production, suggesting a mechanism for hypertriglyceridemia in insulin-resistant states.
Pavlic et al. (2008) studied Healthy (n=12). Intralipid/heparin infusion vs. Glycerol infusion and saline was evaluated on Triglyceride-rich lipoprotein (TRL) apoC-III production rate and fractional catabolic rate. Acute elevation of plasma free fatty acids via Intralipid/heparin infusion significantly increased triglyceride-rich lipoprotein apoC-III production by 90% and fractional catabolic rate by 30%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: