February 22, 2007Journal of Lipid ResearchOpen Access

Rapid turnover of apolipoprotein C-III-containing triglyceride-rich lipoproteins contributing to the formation of LDL subfractions

View Full Paper

Ask AI

Bookmark

Population

11 hypertriglyceridemic and normolipidemic persons

Design

Other

Authors

CZChunyu ZhengDalian Medical University KCKhoo ChristinaHarvard University IKIkewaki KatsunoriJikei University School of Medicine

Discussion

Member takes

Implication

ApoE may be prioritized over apoC-III for limiting TRL-derived LDL; hypothesis-generating for cardiovascular outcomes in hypertriglyceridemia.

Structured PICO

Population

11 hypertriglyceridemic and normolipidemic persons

Outcome

Kinetics of multiple triglyceride-rich lipoprotein (TRL) and LDL subfractions according to the content of apoC-III and apoEsurrogate

ApoE, rather than apoC-III alone, appears to be the key determinant of the metabolic fate of atherogenic apoC-III-containing TRLs, channeling them toward clearance and reducing LDL formation.

Cite This Study

Zheng et al. (2007) studied this question.

synapsesocial.com/papers/6a718ca28031ec7bb1dd04dc https://doi.org/10.1194/jlr.p600011-jlr200

View Full Paper

Ask AI

Bookmark

February 22, 2007Journal of Lipid ResearchOpen Access

Rapid turnover of apolipoprotein C-III-containing triglyceride-rich lipoproteins contributing to the formation of LDL subfractions

View Full Paper

Ask AI

Bookmark

Population

11 hypertriglyceridemic and normolipidemic persons

Design

Other

Authors

CZChunyu ZhengDalian Medical University KCKhoo ChristinaHarvard University IKIkewaki KatsunoriJikei University School of Medicine

Discussion

Member takes

Implication

ApoE may be prioritized over apoC-III for limiting TRL-derived LDL; hypothesis-generating for cardiovascular outcomes in hypertriglyceridemia.

Structured PICO

Population

11 hypertriglyceridemic and normolipidemic persons

Outcome

Kinetics of multiple triglyceride-rich lipoprotein (TRL) and LDL subfractions according to the content of apoC-III and apoEsurrogate

ApoE, rather than apoC-III alone, appears to be the key determinant of the metabolic fate of atherogenic apoC-III-containing TRLs, channeling them toward clearance and reducing LDL formation.

Cite This Study

Zheng et al. (2007) studied this question.

synapsesocial.com/papers/6a718ca28031ec7bb1dd04dc https://doi.org/10.1194/jlr.p600011-jlr200

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark