Progressive hematopoietic stem cell mobilization during human pregnancy is associated with cholesterol metabolism

Christine Nkemeh; Brandon Vu; Itaevia Curry-Chisolm; Shontreal Cooper; Roshini Zachariah; Wenqi Gan; Charissa J. Okang; Makayla Murphy; Kwong-Wai Choy; Winston A. Campbell; Andrea Shields; Jeffrey G. McDonald; Hideyuki Oguro

doi:10.3324/haematol.2026.301400

September 10, 2026HaematologicaOpen Access

Progressive hematopoietic stem cell mobilization during human pregnancy is associated with cholesterol metabolism

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Key Points

To characterize the mobilization of hematopoietic stem cells across human pregnancy and identify its association with systemic cholesterol metabolism.
Monitored circulating hematopoietic stem and progenitor cell levels in maternal peripheral blood throughout gestation.
Profiled lipid panels and markers of cholesterol metabolism to evaluate correlations with circulating stem cell dynamics.
Peripheral blood hematopoietic stem cell counts progressively increase across the trimesters of pregnancy.
Stem cell mobilization correlates directly with gestational adaptations in maternal cholesterol metabolic pathways.

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Implication

Observational study reveals progressive hematopoietic stem cell mobilization in pregnant women, suggesting a regulatory role for cholesterol metabolism.

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Cite This Study

Nkemeh et al. (2026) studied this question.

synapsesocial.com/papers/6aa51ef5327956e4761f8f98 https://doi.org/10.3324/haematol.2026.301400

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Progressive hematopoietic stem cell mobilization during human pregnancy is associated with cholesterol metabolism

Key Points

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Implication

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Cite This Study

Progressive hematopoietic stem cell mobilization during human pregnancy is associated with cholesterol metabolism

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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