Key result
Sepsis and inflammation linked to lower mean platelet component values in horses versus healthy controls.
Why the study?
Does mean platelet component (MPC) serve as an indicator of platelet activation in sick foals and adult horses?
Population
100 sick and 20 healthy neonates, and 178 sick and 45 sound adult horses
Comparison
Measurement of mean platelet component and other… vs Healthy control groups
Design
Preclinical
Authors
Loading...
MPC reduction may indicate platelet activation in equine disease; hypothesis-generating and should not yet change practice.
Observational (n=343)
Does mean platelet component (MPC) serve as an indicator of platelet activation in sick foals and adult horses?
Mean platelet component is significantly reduced in sick horses and neonates, suggesting it may serve as a rapid and accessible marker for platelet activation and disseminated intravascular coagulation in veterinary medicine.
Segura et al. (2007) conducted an observational in Clinical conditions causing platelet activation and disseminated intravascular coagulation (n=343). Clinical conditions causing platelet activation (e.g., sepsis, inflammation, DIC) vs. Healthy/sound control horses was evaluated on Mean platelet component (MPC) values. Clinical conditions such as sepsis and inflammation were associated with significantly lower mean platelet component values in both neonate and adult horses compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: