Key result
Thrombin-activated equine platelets exhibit stronger subendothelial reactivity than human platelets alongside increased P-selectin binding.
Population
Equine platelets (horses)
Comparison
Ultrastructure examination, flow cytometry, and… vs Human platelets (for perfusion experiments)
Design
Preclinical
Authors
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Adapts human platelet assays to equine models; leaves open translation to clinical equine thrombosis care.
Techniques used to assess human platelet function, such as flow cytometry and perfusion, can be effectively adapted to evaluate equine platelet function despite some species differences.
Segura et al. (2006) studied this question. Platelet activation (thrombin/collagen) and perfusion vs. Resting platelets / Human platelets was evaluated on Platelet activation marker binding and subendothelium interaction. Thrombin activation of equine platelets increased P-selectin and LIMP binding from 2.12% and 1.74% to 15.5% and 11.6%, respectively, and showed stronger subendothelial reactivity than human platelets.
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