Key result
Coronary occlusion in dogs drives S-T shifts within 20 seconds secondary to primary injury current.
Population
7 dogs undergoing coronary artery occlusion
Design
Preclinical
Follow-up
15 minutes
Authors
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Clarifies injury-current mechanism of ST shifts in canine ischemia; leaves open translation to human ECG interpretation and practice.
The study demonstrates that during acute ischemia, the S-T shift is a secondary result of a primary injury current that is interrupted during the S-T interval.
Cohen et al. (1975) studied Acute ischemia and infarction (n=7). Coronary artery occlusion vs. Baseline (pre-occlusion) was evaluated on S-T segment shift and base-line (d-c) shifts. Coronary artery occlusion in dogs produced equal and opposite S-T segment and base-line shifts within 20 seconds, indicating the S-T shift is a secondary result of a primary injury current.
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