Key result
Increasing nonpulsatile bypass flow in simulated HF raises mean aortic pressure while reducing cardiac output.
Why the study?
Does simulated nonpulsatile left ventricular bypass alter hemodynamic parameters and pulsatility in a model of left heart failure?
Population
Computer simulation circuit representing the circulatory system with simulated left heart failure
Comparison
Simulated nonpulsatile left ventricular bypass vs Varying levels of bypass flow / unassisted state
Design
Preclinical
Authors
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Should not change VAD strategies in left heart failure; leaves open clinical relevance of simulated nonpulsatile flow effects.
Does simulated nonpulsatile left ventricular bypass alter hemodynamic parameters and pulsatility in a model of left heart failure?
A computer simulation demonstrates that increasing nonpulsatile left ventricular bypass flow alters key hemodynamic parameters, reducing pulsatility and cardiac output while increasing mean aortic pressure.
Mitsui et al. (1996) studied Left heart failure (simulated). Nonpulsatile left ventricular assistance was evaluated on Hemodynamics (mean aortic pressure, tension time index, diastolic pressure time index, cardiac output, pulse pressure, and pulsatility indicator). In a computer simulation of left heart failure, increasing nonpulsatile bypass flow increased mean aortic pressure, tension time index, and diastolic pressure time index, while decreasing cardiac output, pulse pressure, and pulsatility indicator.
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