Key result
Serum periostin levels do not differ between positive and negative API in recurrent preschool wheezers.
Why the study?
Do serum periostin levels differ between recurrent wheezer pre-schoolers with positive versus negative asthma predictive index?
Case-Control (n=48)
No
Do serum periostin levels differ between recurrent wheezer pre-schoolers with positive versus negative asthma predictive index?
Effect estimate: AUC 0.5 (95% CI 0.29-0.70)
Absolute Event Rate: 46.7% vs 67.5%
p-value: p=0.9
Serum periostin levels do not significantly differ between recurrent wheezer pre-schoolers with positive and negative asthma predictive index.
Serum periostin shows no association with asthma predictive index in wheezers; leaves open its utility in larger prospective studies.
BACKGROUND: In contrast to adult asthmatic patients, studies on the role of serum periostin levels in schoolchildren with asthma are still conflictive, and very few studies have been performed in pre-schoolers. The aim of this study was to compare serum periostin levels in recurrent wheezer pre-schoolers according to their asthma predictive index (API) condition. METHODS: We performed a case-control study enrolling pre-schoolers with recurrent wheezing episodes (>3 episodes confirmed by physician) presented at one paediatric clinic in Santiago, Chile. The population was divided according to stringent API criteria into positive or negative. RESULTS: In a one-year period, 60 pre-schoolers were enrolled. After excluding 12 (due to not fulfilment of inclusion criteria or refusal of blood sample extraction), 48 remaining pre-schoolers (27 males, age range from 24 to 71 months) completed the study; 34 were API positive and 14 were API negative. There were no significant differences in demographics between groups. The level of serum periostin levels for pre-schoolers with positive API and negative API were (median 46.7 [25.5-83.1] and 67.5 [20.5-131.8], p=0.9, respectively). The area under the curve for the serum periostin levels for predict positive API was 0.5, 95% CI [0.29-0.70], p=0.9. No significant correlation between serum periostin levels and peripheral blood eosinophils was found. CONCLUSION: Serum periostin levels were no significantly different between wheezer pre-schoolers with positive and negative API. More studies are needed to confirm this finding.
No takes yet. Share an insight, caveat, or question.
Castro‐Rodríguez et al. (2017) conducted a case-control in Recurrent wheezing (n=48). Positive asthma predictive index (API) vs. Negative asthma predictive index (API) was evaluated on Serum periostin levels (AUC 0.5, 95% CI 0.29-0.70, p=0.9). Serum periostin levels did not significantly differ between recurrent wheezer pre-schoolers with positive versus negative asthma predictive index (median 46.7 vs 67.5; p=0.9).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: