What question did this study set out to answer?

To evaluate mortality, healthcare utilization, and costs among Medicare beneficiaries aged 65 years and older with primary or recurrent Clostridioides difficile infection, examining how clinical outcomes associate with mortality.

March 11, 2022Journal of the American Medical Directors AssociationOpen Access

Mortality, Health Care Use, and Costs of Clostridioides difficile Infections in Older Adults

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Authors

PFPaul FeuerstadtYale University WNWinnie W. NelsonHelsinn Therapeutics (United States)EDEdward DrozdPrevea Health

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Implication

Observational claims analysis demonstrates sharply increased mortality and healthcare costs following recurrent Clostridioides difficile in older adults, highlighting urgent prevention needs.

Key Points

To evaluate mortality, healthcare utilization, and costs among Medicare beneficiaries aged 65 years and older with primary or recurrent Clostridioides difficile infection, examining how clinical outcomes associate with mortality.
Retrospective observational claims analysis using 100% Medicare Fee-for-Service claims data from 2009 to 2017 with continuous enrollment in Parts A, B, and D for 12 months pre- and post-index.
Identified primary CDI (pCDI, n = 345,893) and recurrent CDI (rCDI, n = 151,596) episodes to evaluate outcomes over a follow-up of up to 12 months.
Estimated multivariable regression models adjusting for baseline comorbidities to evaluate hospitalization risk, hospital length of stay, intensive care unit utilization, and healthcare costs per patient per month.
CDI-associated mortality was nearly tenfold higher after recurrent infection (25.4%) compared with primary infection (2.7%).
Adjusting for comorbidities, decedents experienced significantly increased hospitalization rates compared to survivors (pCDI: OR = 1.83, P < .001; rCDI: OR = 2.58, P < .001) and elevated intensive care unit use during recurrent episodes (OR = 2.34, P < .001).
Decedents had significantly extended hospital stays (pCDI: +3.2 days, P < .001; rCDI: +2.6 days, P < .001) and higher total healthcare costs (pCDI: +303%, P < .001; rCDI: +297%, P < .001) relative to survivors.

Cite This Study

Feuerstadt et al. (2022) studied this question.

synapsesocial.com/papers/6aa53384bc2c7db7488e34be https://doi.org/10.1016/j.jamda.2022.01.075

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Implication

Observational claims analysis demonstrates sharply increased mortality and healthcare costs following recurrent Clostridioides difficile in older adults, highlighting urgent prevention needs.

Mortality, Health Care Use, and Costs of Clostridioides difficile Infections in Older Adults

Discussion

Member takes

Implication

Key Points

Cite This Study

Mortality, Health Care Use, and Costs of Clostridioides difficile Infections in Older Adults

Discussion

Member takes

Implication

Key Points

Cite This Study

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