Why the study?
Does ultrasound-facilitated, catheter-directed thrombolysis with alteplase reduce adverse clinical outcomes in patients with intermediate-high-risk pulmonary embolism compared to anticoagulation alone?
Population
544 patients with intermediate-high-risk pulmonary embolism
Comparison
Ultrasound-facilitated, catheter-directed… vs Anticoagulation alone
Design
Review, randomized, lack of blinding
Key result
Ultrasound-facilitated, catheter-directed thrombolysis with alteplase reduced the composite of PE-related death, decompensation, or recurrence compared with anticoagulation alone (4% vs 10%).
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RCT evidence informs emergency protocols now; extends prior data with randomized confirmation.
RCT (n=544)
Open-label
randomized
Does ultrasound-facilitated, catheter-directed thrombolysis with alteplase reduce adverse clinical outcomes in patients with intermediate-high-risk pulmonary embolism compared to anticoagulation alone?
Absolute Event Rate: 4% vs 10%
Ultrasound-facilitated catheter-directed thrombolysis reduces clinical decompensation in intermediate-high-risk PE compared to anticoagulation alone, supporting its use in this population.
A 2026 study conducted an RCT in Intermediate-high-risk pulmonary embolism (n=544). Ultrasound-facilitated, catheter-directed thrombolysis with alteplase vs. Anticoagulation alone was evaluated on Composite outcome of PE-related death, cardiorespiratory decompensation, or symptomatic PE recurrence. Ultrasound-facilitated, catheter-directed thrombolysis with alteplase reduced the composite of PE-related death, decompensation, or recurrence compared with anticoagulation alone (4% vs 10%).
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