Key result
Naloxone raises MAP by ~17 mm Hg in septic shock without improving overall mortality.
Why the study?
Does naloxone improve hemodynamics in patients with septic shock resistant to fluid challenge?
Population
13 consecutive patients with documented septic shock and resistance to a one-liter fluid challenge
Design
Case_series
Follow-up
1 hour
Authors
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May transiently raise MAP in fluid-refractory septic shock but should not change practice; leaves open outcome benefit pending RCTs.
Does naloxone improve hemodynamics in patients with septic shock resistant to fluid challenge?
Absolute Event Rate: 77% vs 60%
p-value: p=<0.005
Naloxone administration in fluid-resistant septic shock significantly increases mean and systolic arterial pressure but has no demonstrated effect on overall mortality.
Hackshaw et al. (1990) studied septic shock (n=13). Naloxone was evaluated on mean arterial pressure (MAP) at 5 min (p=<0.005). Naloxone administration in patients with septic shock significantly increased mean arterial pressure from 60 mm Hg at baseline to 77 mm Hg at 5 minutes (p<0.005), with no overall effect on mortality.
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