Key result
Sleep-disordered breathing correlates with larger baseline brachial artery diameter but not endothelial dysfunction.
Why the study?
Does sleep-disordered breathing severity correlate with altered brachial artery diameter and flow-mediated dilation in a community-based cohort?
Population
682 adults, aged 42-83 years, from the Framingham Heart Study site of the Sleep Heart Health Study.
Comparison
Sleep-disordered breathing severity quantified… vs Lower severity categories of apnea-hypopnea index
Design
Cross-sectional
Authors
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May indicate vascular remodeling without endothelial dysfunction in sleep-disordered breathing; hypothesis-generating and requires longitudinal validation before clinical consideration.
Cross-Sectional (n=682)
Does sleep-disordered breathing severity correlate with altered brachial artery diameter and flow-mediated dilation in a community-based cohort?
p-value: p=0.03
Sleep-disordered breathing is associated with larger baseline brachial artery diameter, suggesting vascular remodeling, but not with endothelial dysfunction as measured by flow-mediated dilation.
Chami et al. (2009) conducted a cross-sectional in Sleep-disordered breathing (n=682). Sleep-disordered breathing vs. No or mild sleep-disordered breathing was evaluated on Baseline brachial artery diameter (p=0.03). Sleep-disordered breathing was associated with larger baseline brachial artery diameter (p=0.03), but not with endothelial dysfunction as measured by flow-mediated dilation.
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