Key result
GW395058 increases rat platelet counts ~4-fold with prolonged serum half-lives in animal models.
GW395058 demonstrates prolonged half-life and dose-dependent thrombocytosis in rats, with differing hematological responses in monkeys.
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Serres et al. (1999) studied thrombocytopenia. GW395058 was evaluated on Pharmacokinetics and platelet counts. GW395058 administration increased rat platelet counts up to fourfold at 10 microg/kg s.c., with serum half-lives >20 hours in rats and 37-68 hours in monkeys.
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