Why the study?
Does AMG 531 increase platelet counts and what are its pharmacokinetics and tolerability in healthy subjects?
Population
48 healthy subjects
Comparison
Single intravenous or subcutaneous injection of… vs Placebo
Design
RCT, sequentially randomized in a 2:1 ratio, double-blind
Follow-up
28 days
Authors
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Supports advancement to patient trials in thrombocytopenia; extends first-in-human RCT data on AMG 531 dosing and safety.
Does AMG 531 increase platelet counts and what are its pharmacokinetics and tolerability in healthy subjects?
AMG 531 is well tolerated and effectively raises platelet counts in healthy volunteers after a single intravenous or subcutaneous dose.
Wang et al. (2004) studied this question.
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