Key result
Higher 24-hour postoperative glucose variability linked to ~16% greater atrial fibrillation risk after CABG.
Why the study?
Elevated preoperative HbA1c predicts poor outcomes after CABG, but the role of increased postoperative glucose variability was unknown.
Does increased postoperative glucose variability increase the risk of postoperative atrial fibrillation in patients undergoing isolated CABG?
Population
2073 patients who underwent isolated CABG
Comparison
Postoperative glucose variability in the first 24 hours
Design
Multicenter retrospective study
Authors
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Does not support changing glucose management protocols; leaves open whether variability is a modifiable target or marker for post-CABG AF.
Cohort (n=2,073)
Yes
Does increased postoperative glucose variability increase the risk of postoperative atrial fibrillation in patients undergoing isolated CABG?
Odds Ratio: 1.16 (95% CI 1.05–1.27)
p-value: p=< 0.01
Increased 24-hour postoperative glucose variability and mean glucose are independent predictors of atrial fibrillation following isolated CABG, whereas preoperative HbA1c is not.
Clement et al. (2019) conducted a cohort in Coronary artery bypass grafting (CABG) (n=2,073). Increased postoperative glucose variability was evaluated on Postoperative atrial fibrillation (OR 1.16, 95% CI 1.05-1.27, p=< 0.01). Increased 24-hour postoperative glucose variability was associated with an increased risk of postoperative atrial fibrillation following isolated CABG (OR 1.16; 95% CI 1.05-1.27; P<0.01).
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