Key result
Higher preoperative HbA1c linked to ~45% lower risk of postoperative AF after off-pump CABG.
Why the study?
A significant association between diabetes mellitus and postoperative atrial fibrillation after coronary bypass grafting has not been found, and the relationship between preoperative hemoglobin A1c and postoperative AF has not been sufficiently examined.
Does preoperative hemoglobin A1c level predict postoperative atrial fibrillation in patients undergoing isolated off-pump coronary bypass surgery?
Population
805 patients undergoing isolated off-pump coronary bypass surgery excluding emergency, chronic AF, and pacemaker rhythm cases
Comparison
Preoperative hemoglobin A1c levels categorized into tertiles and analyzed continuously
Design
Retrospective cohort study
Follow-up
Postoperative period
Authors
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Higher preoperative HbA1c may aid postoperative AF risk stratification after off-pump CABG; leaves open causal mechanisms and prospective validation.
Cohort (n=805)
Does preoperative hemoglobin A1c level predict postoperative atrial fibrillation in patients undergoing isolated off-pump coronary bypass surgery?
Odds Ratio: 0.55 (95% CI 0.35–0.88)
Absolute Event Rate: 12.5% vs 28.3%
p-value: p=0.01
Lower preoperative hemoglobin A1c levels are independently associated with an increased risk of postoperative atrial fibrillation after off-pump coronary bypass surgery.
Kinoshita et al. (2011) conducted a cohort in Isolated off-pump coronary bypass surgery (n=805). Preoperative hemoglobin A1c vs. Lower hemoglobin A1c levels was evaluated on Postoperative atrial fibrillation (OR 0.55, 95% CI 0.35-0.88, p=0.01). Higher preoperative hemoglobin A1c independently predicted a lower risk of atrial fibrillation after off-pump coronary bypass grafting (adjusted OR 0.55; 95% CI 0.35-0.88 for upper vs lower tertile).
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