Key result
Bone marrow mononuclear cell transplantation reverses RV dilatation in a Chagas disease mouse model.
Why the study?
Does bone marrow mononuclear cell transplantation reverse right ventricular dilatation in a mouse model of Chagasic cardiomyopathy?
Does bone marrow mononuclear cell transplantation reverse right ventricular dilatation in a mouse model of Chagasic cardiomyopathy?
Bone marrow cell therapy reverses right ventricular dilatation in a mouse model of Chagasic cardiomyopathy, extending previous evidence of its anti-inflammatory and anti-fibrotic effects.
Hypothesis-generating for cell therapy in Chagasic cardiomyopathy; extends prior anti-inflammatory observations to RV remodeling in mice.
Chronic chagasic cardiomyopathy, which is caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. It is a disease for which effective treatment in its advanced clinical forms is lacking. We have previously shown that bone marrow mononuclear cell (BMC) transplantation is effective in reducing inflammation and fibrosis in the mouse model of Chagas disease. The present study used magnetic resonance imaging to assess changes in the cardiac morphology of infected mice after therapy with BMCs. Serial imaging of the BMC-treated mice revealed regression of the right ventricular dilatation typically observed in the chagasic mouse model.
No takes yet. Share an insight, caveat, or question.
Goldenberg et al. (2008) studied Chronic chagasic cardiomyopathy. Bone marrow mononuclear cell (BMC) transplantation was evaluated on Changes in cardiac morphology (regression of right ventricular dilatation) assessed by MRI. Bone marrow mononuclear cell transplantation led to regression of right ventricular dilatation in a mouse model of Chagas disease as assessed by serial magnetic resonance imaging.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: