Key result
Elevated D-dimer predicts ~125% higher postoperative spinal cord injury risk in ATAAD, alongside decreased platelets.
Why the study?
This study aimed to identify the risk factors contributing to spinal cord injury following type A acute aortic dissection.
Do preoperative platelet count and D-dimer levels predict postoperative spinal cord injury in patients undergoing surgery for type A acute aortic dissection?
Cohort (n=481)
No
Do preoperative platelet count and D-dimer levels predict postoperative spinal cord injury in patients undergoing surgery for type A acute aortic dissection?
Answers are grounded in this paper and cite their sources.
Preoperative platelet count and D-dimer levels may serve as independent predictors for postoperative spinal cord injury in patients undergoing surgery for type A acute aortic dissection.
Background This study aims to identify the risk factors contributing to spinal cord injury (SCI) following a type A acute aortic dissection (TA-AAD).Methods This retrospective study was conducted at a single center and involved 481 patients who received frozen elephant trunk stent implantation for TA-AAD and underwent total arch replacement with the deep hypothermic circulatory arrest at Fuwai Hospital between September 2016 and April 2020.Results The resulting data of the multivariate logistic regression analysis demonstrated that preoperative platelet count (odds ratio [OR] 0.774) and D-dimer levels (OR 2.247) held potential as independent predictors for postoperative SCI in patients diagnosed with TA-AAD.Conclusion The study results indicated that preoperative platelet count and D-dimer levels are independent risk factors for postoperative SCI in individuals with TA-AAD. This finding holds significance regarding clinical implications for prognosis and therapeutic responses in TA-AAD.
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Pei et al. (2023) conducted a cohort in Type A acute aortic dissection (TA-AAD) (n=481). Preoperative D-dimer levels and platelet count vs. Normal levels was evaluated on Postoperative spinal cord injury (SCI) (OR 2.247, 95% CI 1.756-4.226, p=0.016). Elevated preoperative D-dimer levels and decreased platelet counts were identified as independent risk factors for postoperative spinal cord injury in patients with acute type A aortic dissection.
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