Key result
Higher admission D-dimer linked to ~19% greater 90-day postoperative adverse event risk per 10 µg/mL.
Why the study?
The study investigated the associations between admission D-dimer levels and early adverse events in patients with acute type A aortic dissection undergoing arch replacement and frozen elephant trunk implantation.
Do D-dimer levels at admission predict 90-day postoperative adverse events in patients with acute type A aortic dissection undergoing arch replacement and FET?
Population
347 patients with acute type A aortic dissection undergoing arch replacement and FET
Comparison
Admission D-dimer levels
Design
Retrospective cohort study
Follow-up
90 days
Authors
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Admission D-dimer was associated with early adverse events after FET; hypothesis-generating for risk stratification in type A dissection.
Cohort (n=347)
No
Do D-dimer levels at admission predict 90-day postoperative adverse events in patients with acute type A aortic dissection undergoing arch replacement and FET?
Hazard Ratio: 1.19 (95% CI 1.01–1.41)
p-value: p=0.039
Elevated admission D-dimer levels independently predict 90-day adverse events (mortality and permanent neurological dysfunction) in patients undergoing surgery for acute type A aortic dissection.
Liu et al. (2020) conducted a cohort in Acute type A aortic dissection (n=347). D-dimer levels at admission vs. Lower D-dimer levels was evaluated on 90-day postoperative adverse events (all-cause mortality or permanent neurological dysfunction) (HR 1.19, 95% CI 1.01-1.41, p=0.039). Increased D-dimer levels at admission were independently associated with a higher risk of 90-day postoperative adverse events (HR 1.19 per 10 ug/ml increase) in patients with acute type A aortic dissection undergoing arch replacement and FET.
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