Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1988Journal of Lipid ResearchOpen Access

Interactions of high density lipoproteins with very low and low density lipoproteins during lipolysis.

View Full Paper
Ask AI
Bookmark
Share

Key result

Increasing HDL progressively reduces VLDL-LDL complex formation during in vitro lipolysis.

Population

In vitro lipoprotein models (HDL, VLDL, LDL)

Comparison

In vitro lipolysis with increasing… vs Lower concentrations or absence of HDL

Design

Preclinical

Authors

HMH J MichenfelderRKR M KraussUniversity of Arizona

Discussion

Loading...

Member takes

Implication

May support HDL-mediated lipoprotein remodeling in vitro; leaves open in vivo relevance and clinical implications.

Structured PICO

P
Population
In vitro lipoprotein models (HDL, VLDL, LDL)
E
Exposure
In vitro lipolysis with increasing concentrations of HDL or delipidated HDL
C
Comparator
Lower concentrations or absence of HDL
O
Outcome
VLDL-LDL complex formation and association of apoA-I with VLDL and LDLsurrogate

In vitro lipolysis products promote physical complex formation and lipid/apolipoprotein transfers between HDL, VLDL, and LDL, which may facilitate intravascular lipoprotein remodeling.

Cite This Study

Michenfelder et al. (1988) studied this question. High density lipoproteins (HDL) was evaluated on VLDL-LDL complex formation and apolipoprotein A-I association. Increasing concentrations of HDL progressively diminished VLDL-LDL complex formation during in vitro lipolysis, promoting multiple interactions at the surface of triglyceride-rich lipoproteins.

synapsesocial.com/papers/6aa547a69feada129378e252https://doi.org/10.1016/s0022-2275(20)38540-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reversible modification of human plasma low density lipoproteins toward triglyceride-rich precursors. A mechanism for losing excess cholesterol esters.1982 · 162 citations
  2. 2Presence of multiple subpopulations of lipoproteins of intermediate density in normal subjects.1986 · 88 citations
  3. 3Lipoprotein lipase enhances the cholesteryl ester transfer protein-mediated transfer of cholesteryl esters from high density lipoproteins to very low density lipoproteins.1984 · 94 citations
  4. 4Identification of multiple subclasses of plasma low density lipoproteins in normal humans.1982 · 995 citations
  5. 5Selective Measurement of Two Lipase Activities in Postheparin Plasma from Normal Subjects and Patients with Hyperlipoproteinemia1974 · 439 citations