Key result
Alpha7-nAChR deficiency in mice does not alter resting autonomic tone or vagal heart rate responses.
Why the study?
Does the alpha7-nAChR subunit contribute to resting parasympathetic control of the heart in mice?
Population
Normal (C57BL/6J), alpha7-deficient (Chrna7), and wild-type littermate mice
Comparison
Genetic deletion of alpha7-nAChR subunit vs Normal (C57BL/6J) and wild-type littermate mice
Design
Preclinical
Authors
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Alpha7-nAChR is not required for resting parasympathetic heart rate control in mice; leaves open its role in human autonomic regulation or disease.
Does the alpha7-nAChR subunit contribute to resting parasympathetic control of the heart in mice?
The alpha7-nicotinic acetylcholine receptor subunit is not required for resting parasympathetic control of the heart in mice.
Deck et al. (2005) studied this question. alpha7-nAChR subunit deficiency vs. Normal and wild-type littermate mice was evaluated on Resting autonomic tone and heart rate response to vagus nerve stimulation. Mice deficient in the alpha7-nAChR subunit showed no differences in resting autonomic tone or heart rate responses to vagus nerve stimulation compared to normal and wild-type mice.
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